Defect in B Cell Function in HTLV ItI / LAV Positive Hemophilia Patients
نویسنده
چکیده
The capacity of the peripheral blood lymphocytes (PBL) to generate an antibody response in vitro to T cell-dependent antigen ovalbumin was studied in 12 severe hemophilia patients who were otherwise in good health. PBL from four of 1 2 patients were not capable of generating such a response after stimulation in vitro, whereas all controls were normal. This negative plaque-forming cell (PFC) response coincided with the presence of antibodies directed toward human T-lymphotropic virus Ill/lymphadenopathy-associated virus (HTLV-lll/LAV). Only one patient with antibodies against HTLV-llI/LAV had a normal PFC response. The negative PFC response was not due to a deficient T helper cell activity, nor to an excessive T
منابع مشابه
Defect in B cell function in HTLV III/LAV positive hemophilia patients.
The capacity of the peripheral blood lymphocytes (PBL) to generate an antibody response in vitro T cell-dependent antigen ovalbumin was studied in 12 severe hemophilia patients who were otherwise in good health. PBL from four of 12 patients were not capable of generating such a response after stimulation in vitro, whereas all controls were normal. This negative plaque-forming cell (PFC) respons...
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